Scions of Tsathoggua

The Scions of Tsathoggua are enormous, bloated, toad-like things. They produce a child-like tittering that has earned them the alternative monicker, The Children of Tsathoggua. They act as the agents and guardians of their sire, Tsathoggua, at its various temples. 

In the RPG...

The Scions only take minimum damage from physical weapons, though fire, chemicals, electricity, and magic harm them normally. Though they can use their tentacles and bite to attack, being trampled is an Investigator's biggest concern. Whereas their tentacles average 10 damage and a bite averages 14, a trampling averages 21! In fact, there's only a 0.45% chance that an average Investigator wouldn't die from a single trampling.

    The 7e Malleus Monstrorum has changed the ranges of the Scion's CON, DEX, and POW.

In a video game...

Because of their role as Tsathoggua's agents, I could see these creatures serving a story role in a video game. The player would probably have to be stocked up on fire weaponry before the encounter, however.

In a film...

I think the Scions of Tsathoggua would be cool in a film about their sire. If the Formless Spawn were also included, you would have a potentially horrific movie on your hands.